Awarded a $2.5 million grant from the National Cancer Institute, a division of the National Institutes of Health (NIH), to study predictive testing of ocular (or uveal) melanoma. Learn more.
Discovered that the histone deacetylase inhibitor vorinostat, clinically approved by the FDA to treat a rare form of lymphoma, may be repurposed to also treat uveal melanoma. In the laboratory, vorinostat was able to transform aggressive uveal melanoma cells into more normal-appearing cells. Learn more
Discovered that mutations in the tumor suppressor gene BAP1 are responsible for metastatic death in uveal melanoma.
Discovered that histone deacetylase inhibitors reverse the biochemical effects of BAP1 mutation and may have a role in targeted therapy of uveal melanoma metastasis.
Discovered a gene expression signature that predicts metastasis in uveal melanoma. This discovery has led to a routine clinical test that is used around the world.
Discovered that the retinoblastoma protein is regulated by a hierarchical series of intramolecular conformational changes catalyzed by discrete phosphorylation events.
Discovered that mutations in the retinoblastoma gene occur in most small cell lung cancers.