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Bascom Palmer Eye Institute

Ocular Microbiology Research Core and Interests

The Ocular Microbiology Research Core collaborates with faculty, researchers, staff and students in a wide range of studies and projects related to the epidemiology, pathobiology and prevention of ocular infections to provide improved pathogen detection, appropriate antimicrobial selection, and reduced ocular morbidity in the management and prevention of ocular infectious disease.

Leadership & Management

Eduardo C. Alfonso, MD, Professor and Chair of Ophthalmology serves as the Medical Director of the Ocular Microbiology Core. Darlene Miller, Research Associate Director is the Scientific Director and imitates and collaborates on research projects and studies. Jorge Maestre-Mesa, MD, PhD is our molecular biology expert and is instrumental in molecular studies on ocular microbiomes and individual microbes. Medical Technologists, Edith Perez, BS, MT (ASCP) and Martha Diaz, BS MT (ASCP-retiring), assist in maintaining the ocular microbiology databank.

Location

The Ocular Microbiology Research Core is located on the 1st floor of the McKnight Research Building

Research Interests

Current research interest includes:

  • investigation of the epidemiology and pathology of ocular infectious diseases.
  • emerging antibiotic resistance and treatment outcomes.
  • impact of biofilm on the recovery and treatment of ocular infections.
  • diversity of the ocular microbiome in health and disease
  • mechanism of interspecies signaling in ocular infections
  • role of Infection control and prevention in reducing ocular infections and antibiotic resistance
  • the use of technology for the rapid detection of ocular pathogens in ocular tissues and fluids.
  • collaboration with colleagues and experts in ophthalmology, industry and epidemiology to broaden our knowledge base and improve understanding of the pathogenesis of ocular infectious diseases

Scientific Articles (PubMed):

Darlene Miller, 2000-2006

  • Fernandez V, Dursun D, Miller D, Alfonso EC.
    Colletotrichum keratitis.
    Am J Ophthalmol. 2002 Sep;134(3):435-8.
    PMID: 12208257 [PubMed – indexed for MEDLINE]
  • Alexandrakis G, Palma LA, Miller D, Alfonso EC.
    Capnocytophaga keratitis.
    Ophthalmology. 2000 Aug;107(8):1503-6.
    PMID: 10919898 [PubMed – indexed for MEDLINE]