Abigail S. Hackam, Ph.D.
- Associate Professor of Ophthalmology
- Graduate faculty in Neuroscience, Human Genetics and Genomics, and Molecular and Cellular Pharmacology
The research in Dr. Hackam’s laboratory encompasses the fields of genetics, inflammation and ophthalmology. Our focus is on understanding signaling mechanisms that contribute to retinal degeneration and tumorigenesis, through the use of cellular, molecular and bioinformatics analyses.
1. Identification of photoreceptor protection proteins: The role of Wnt signaling pathway in retinal degeneration.
2. Investigating the role of toll-like receptors in retinal degeneration.
3. Identification of signaling pathways that regulate optic nerve regeneration.
4. Mechanisms of tumorigenesis and cancer stem cell proliferation in ocular cancer.
5. Drug discovery for vision diseases.
Developmental Biology B.Sc. (Honours)
University of Windsor
Windsor, Ontario, Canada
Human Genetics Ph.D.
Johns Hopkins University
University of British Columbia
Vancouver, BC, Canada
Wilmer Eye Institute, Johns Hopkins University
- Activation of Wnt/ß-catenin signaling in Muller glia protects photoreceptors in a mouse model of inherited retinal degeneration.
- Reduced photoreceptor death and improved retinal function during retinal degeneration in mice lacking innate immunity adaptor protein MyD88.
- A novel protective role for the innate immunity Toll-Like Receptor 3 (TLR3) in the retina via Stat3.
- To search for publications by this doctor, visit the National Library of Medicine website.